琥珀酸亚铁（Ferrous Succinate）：辅助治疗糖尿病肾病腹膜透析患者肾贫血

肾性贫血是DNCAPD患者常见的并发症之一,其主要是促红细胞生成素绝对或相对不足、显性或隐性失血、造血原料(维生素 B??、铁、叶酸)的缺乏、红细胞丢失增多及一些酸性代谢产物的潴留等。DN患者贫血的发生率明显高于非DN患者,贫血不仅是DN患者肾功能进展的独立危险因素,也是导致患者死亡的危险因素。

琥珀酸亚铁（Ferrous Succinate）是一种有机铁盐，含25%铁的元素，通过胃酸作用解离出琥珀酸根，可参与Hb的合成，从而促进亚铁离子的吸收，进而改善患者贫血症。提升血清铁、转铁蛋白饱和度（TSAT）及铁蛋白水平，纠正功能性铁缺乏。

有机铁盐在胃肠道中的解离速度较无机铁（如硫酸亚铁）更温和，受食物中植酸、鞣酸的影响较小，铁吸收效率更高。琥珀酸亚铁（Ferrous Succinate）的有机酸配体可减少游离铁离子对胃黏膜的刺激，降低恶心、便秘等不良反应发生率，更适合长期用药。

Ferrous Succinate: Adjuvant Therapy for Renal Anemia in Diabetic Nephropathy Patients Undergoing Peritoneal Dialysis

Renal anemia is one of the common complications in diabetic nephropathy patients undergoing peritoneal dialysis (DNCAPD), primarily caused by absolute or relative deficiency of erythropoietin (EPO),显性 or 隐性 blood loss, deficiency of hematopoietic raw materials (vitamin B??, iron, folic acid), increased red blood cell loss, and retention of acidic metabolites. The incidence of anemia in DN patients is significantly higher than that in non-DN patients. Anemia is not only an independent risk factor for the progression of renal function in DN patients but also a risk factor for patient mortality.

Ferrous Succinate, an organic iron salt containing 25% elemental iron, dissociates into succinate through the action of gastric acid, participating in hemoglobin (Hb) synthesis to promote the absorption of ferrous ions and improve anemia. It can elevate serum iron, transferrin saturation (TSAT), and ferritin levels, correcting functional iron deficiency.

Compared with inorganic iron (such as ferrous sulfate), organic iron salts dissociate more mildly in the gastrointestinal tract, are less affected by phytic acid and tannic acid in food, and have higher iron absorption efficiency. The organic acid ligand of Ferrous Succinate reduces the irritation of free iron ions to the gastric mucosa, decreases the incidence of adverse reactions such as nausea and constipation, and is more suitable for long-term use.

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